| Blueprint ID | Learning Objectives |
| 8587 | explain the origins and importance of spontaneous mutagenic events |
| 8588 | describe some of the changes in DNA caused by mutagens: proof reading, excision repair, and mismatch repair |
| 8589 | explain what is meant by an oncogene, and explain the various ways in which they may transform cells |
| 8590 | explain the role of tumour suppressor genes, mutator genes in cancer |
| 8591 | explain the two-hit model for the action of tumour suppressor genes |
| 8592 | explain the progressive and cumulative nature of cancer at the genetic level |
| 8593 | describe how a predisposition to cancer can be transmitted to offspring |
| 8594 | describe the characteristics of inherited colorectal and breast cancers |
| 8595 | describe how the clinical presentation of inherited cancers may differ from that of sporadic cancers |
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