 
Class of 2017
 Go Back | | Session Title: | | Biological Membranes, Electrolyte Transport & H2O Movement | | | Teaching Hours: | | Teaching and Learning Methods | Total Scheduled Hours = 1
Lecture = 1 | | Description: | | | Physiology |
| Blueprint ID | Learning Objectives | | 6917 | Describe the composition of a cell membrane. Diagram its cross section, and explain how the distribution of phospholipids and proteins influences the membrane permeability of ions, hydrophilic and hydrophobic compounds. | | 6918 | Write Fick’s Law of diffusion, and explain how changes in the concentration gradient, surface area, time, and distance will influence the diffusional movement of a compound. | | 6919 | Differentiate the following terms based on the source of energy driving the process and the molecular pathway for: diffusion, facilitated diffusion, secondary active transport, and primary active transport. | | 6920 | Describe how transport rates of certain molecules and ions are accelerated by specific membrane transport proteins (“carrier” and “channel” molecules). | | 6921 | Define the following properties of ion channels: gating, activation, and inactivation. Contrast the gating of ion-selective channels by extracellular ligands, intracellular ligands, stretch, and voltage. | | 6922 | Describe how energy from ATP hydrolysis is used to transport ions such as Na+, K+, Ca2+, and H+ against their electrochemical differences (e.g., via the Na+ pump, sarcoplasmic reticulum Ca2+ pump, and gastric H+ pump). | | 6923 | Explain how energy from the Na+ and K+ electrochemical gradients across the plasma membrane can be used to drive the net “uphill” (against a gradient) movement of other solutes (e.g., Na+/glucose co-transport; Na+/Ca2+ exchange or counter-transport). | | 6924 | Differentiate between the terms osmole, osmolarity, osmolality and tonicity. List the typical value and normal range for plasma osmolality. | | 6925 | Using a cell membrane as an example, define a reflection coefficient, and explain how the relative permeability of a cell to water and solutes will generate an osmotic pressure. Contrast the osmotic pressure generated across a cell membrane by a solution of particles that freely cross the membrane with that of a solution with the same osmolality, but particles that cannot cross the cell membrane. | | 6926 | Describe the role of water channels (aquaporins) in facilitating the movement of water across biological membranes. | | |
| Blueprint ID | Course Goals | | 7023 | Integrate basic and clinical sciences as they relate to common clinical encounters and patient symptoms
Linked Program Competencies
To This Course Goal: me-6 | | me-6 | Medical Expert
Apply knowledge of the clinical, socio-behavioural, and fundamental biomedical sciences relevant to a clinical problem. |
| (045) ACID-BASE ABNORMALITIES | | (079-1) HYPERKALEMIA | | (099-1) HYPERNATREMIA | | (012-2) CALCIUM DISORDERS | | (079-2) HYPOKALEMIA | | (099-2) HYPONATREMIA | | (051) ABNORMAL, SERUM LIPIDS |
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