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Bruno Stuyvers

BioMedical Sciences
PhD (INSERM-France)

Professor of Cardiac & Renal Physiology

Division of BioMedical Sciences
Faculty of Medicine
Memorial University of Newfoundland
300 Prince Phillip Drive
St. John's, NL, Canada A1B 3V6
t: 709-864-4932
f: 709-864-6007
lab: 709-864-4933 / 709-864-4934

General interest: sub-cellular mechanisms of cardiac dysfunctions

Specific interests: Physiology and physiopathology of cardiac Purkinje cells.

Our research projects intend to elucidate the triggering mechanism of ventricular fibrillation (VF) and sudden cardiac death (SCD) associated with myocardial ischemia.
We use advanced cell imaging technologies, electrophysiology, and computational modeling to identify, characterize and, potentially, correct the molecular anomalies that impact the conduction (His-Purkinje) system of the heart and creates the lethal arrhythmias.
A translational stength of the laboratory is the use of live Purkinje cells from large mammalian hearts. This enabled us to discover important new insights into the electric function of normal heart. Capitalizing on these recent knowledges, our current research is implementated from
 various experimental models of myocardial infarction and investigates from molecules to the whole organism the source of VF and SCD in patients undergoing heart attacks.

We aknowledge for previous and current support:
- the Canadian Foundation for Innovation (CFI),
- the Canadian Institutes of Health Research (CIHR),
- the Natural Sciences and Engineering Research Council (NSERC),
- the Province of Newfoundland & Labrador (IRIF, RDC),
- the Faculty of Medicine, MUN.


The latest publications... 

Cardiac expression of ryanodine receptor subtype 3; a strategic component in the intracellular Ca2+ release system of Purkinje fibers in large mammalian heart.
Daniels RE, Haq KT, Miller LS, Chia EW, Miura M, Sorrentino V, McGuire JJ, Stuyvers BD.
Journal of Molecular and Cellular Cardiology. 2017 Mar;104:31-42.

Ventricular arrhythmias and the His-Purkinje system
Haissaguerre M, Vigmond E, Stuyvers B, Hocini M, Bernus O.
Nature Reviews Cardiology. 2016 Mar;13(3):155-66. PMID:26727298.
PMID: 26727298

Modeling our understanding of the His-Purkinje system.
Vigmond EJ & Stuyvers BD
Progress in Biophysics and Molecular Biology. 2015.Dec 29.
PMID: 26740015

What is a Ca2+ wave? Is it like an Electrical Wave?
Boyden PA, Dun W, Stuyvers BD.
Arrhythmia and Electrophysiology Review. 2015 May;4(1):35-9

Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury.
Kuster DW, Cardenas-Ospina A, Miller L, Liebetrau C, Troidl C, Nef HM, Möllmann H, Hamm CW, Pieper KS, Mahaffey KW, Kleiman NS, Stuyvers BD, Marian AJ, Sadayappan S.
American Journal of  Physiology  (Heart Circ). 2014 Feb 15 ;306 (4): H547-56

Evoked centripetal Ca2+ mobilization in cardiac Purkinje cells; Insight from a model of three Ca2+ release regions. Kazi T Haq, Rebecca E Daniels, Lawson S Miller, Masahito Miura, Henk EDJ ter Keurs, Sharene D Bungay, Bruno D. Stuyvers.
Journal of Physiology (London) 2013; Sept 1; 591: 4301-4319.

Role of reactive oxygen species and Ca2+ dissociation from the myofilaments in determination of Ca2+ wave propagation in rat cardiac muscle.
Miura M, Murai N, Hattori T, Nagano T, Stuyvers BD, Shindoh C.
Journal of Molecular and Cellular Cardiology. 2013 Mar;56:97-105.


Effect of nonuniform muscle contraction on sustainability and frequency of triggered arrhythmias in rat cardiac muscle.
Miura M, Nishio T, Hattori T, Murai N, Stuyvers BD, Shindoh C, Boyden PA.
Circulation. Electrophysiology and Arrhythmia. 2010 Jun 29;121(25):2711-7

Function of Ca2+ release Channels in Purkinje cells that survive in the Infarcted Canine Heart; a Mechanism for triggered Purkinje Ectopy.
Hirose M, Stuyvers BD, Dun W, ter Keurs HEDJ,Boyden PA.
Circulation. Electrophysiology and Arrhythmia. Dec 2008;1:387-395

Wide Long lasting Perinuclear Ca2+ Release Events Generated by an Interaction between Ryanodine and IP3 Receptors in Canine Purkinje Cell.
Hirose M, Stuyvers BD, Dun W, ter Keurs HEDJ,Boyden PA.
Journal of Molecular and Cellular Cardiology 2008 aug; 45(2): 176-84

Sarcomere Mechanics in Uniform and Nonuniform Cardiac Muscle: A Link between Pump Function and Arrhythmias.
Ter Keurs HE, Shinozaki T, Zhang YM, Wakayama Y, Sugai Y, Kagaya Y, Miura M, Boyden PA, Stuyvers BD, Landesberg A. 
Annals of New York Academy of Sciences. 2008 Mar; 1123: 79-95.

Cellular and Molecular Determinants of Altered Ca2+ Handling in the Failing Rabbit Heart: Primary Defects in SR Ca2+ Uptake and Release Mechanisms.
Armoundas AA, Rose J, Aggarwal R, Stuyvers B, O'rourke B, Kass DA, Marban E, Shorofsky SR, Tomaselli GF, Balke CW.
American Journal of Physiology: Heart Circ Physiol. 2007 Mar; 292(3): H1607-18.

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