Colorectal cancer (CRC) is the third common cancer and one of the leading cause of cancer-related death in industrialized countries. The 5-year mortality rate for CRC is around 35%, therefore, upon the diagnosis, estimates on the disease course (prognosis) and clinical outcome in the patient become important. A variety of factors, including genetic factors, influence the prognosis and clinical outcome (such as treatment response, toxicity and survival) in cancer patients. Identification of these genetic factors facilitate the “personalized medicine” approach in clinic where each patient’s disease will also be managed based on their unique genetic make-up.

     The dbCPCO database aims to curate molecular and genetic findings on the disease features (i.e. clinocopathological features), prognosis and clinical outcome in CRC. In the current version, we summarize the literature findings on the inherited genetic polymorphisms, somatic and germline mutations in nuclear (and mitochondrial) DNA studied in relation to clinicopathological features, treatment response&toxicity, prognosis and survival in CRC. This database is periodically updated and freely available to researchers from non-profit organizations.

There are currently 6857 entries in our database.


Please cite: Savas S, Younghusband B. dbCPCO: A database of genetic markers tested for their predictive and prognostic value in colorectal cancer. Human Mutation (2010) 31:8, 901-907.

Disclaimer: We cannot guarantee that the information in this database is accurate and up-to-date.

Privacy statement: dbCPCO is a freely accessible public database for researchers from non-profit organizations. While no registration or fee is required to access it, for statistical and funding purposes, we collect information related to its access, including but not limited to domain name or IP address, frequency, date and time of access, and the pages visited.