Scientific Publications

Clinical relevance of biochemical and metabolic changes in osteoarthritis.
Zhai G. 
Adv Clin Chem. 2021;101:95-120. doi: 10.1016/bs.acc.2020.06.001. Epub 2020 Jul 7.

The role of metabolomics in precision medicine of osteoarthritis: How far are we?
Zhai G. 
Osteoarthritis and Cartilage Open. 2021, 100170. In Press.

Macrophage migration inhibitory factor may play a protective role in osteoarthritis.
Liu M, Xie Z, Sun G, Chen L, Qi D, Zhang H, Xiong J, Furey A, Rahman P, Lei G, Zhai G.
Arthritis Res Ther. 2021 Feb 20;23(1):59. doi: 10.1186/s13075-021-02442-w.

Association between epidemiological factors and nonresponders to total joint replacement surgery in primary osteoarthritis patients.
Costello CA, Liu M, Furey A, Rahman P, Randell EW, Zhai G.
J Arthroplasty. 2020 Nov 18:S0883-5403(20)31211-0. doi: 10.1016/j.arth.2020.11.020.

Endotypes of primary osteoarthritis identified by plasma metabolomics analysis.
Werdyani S, Liu M, Zhang H, Sun G, Furey A, Randell EW, Rahman P, Zhai G.
Rheumatology (Oxford). 2020 Nov 7:keaa693.

Differential correlation network analysis identified novel metabolomics signatures for non-responders to total joint replacement in primary osteoarthritis patients.
Costello CA, Hu T, Liu M, Zhang W, Furey A, Fan Z, Rahman P, Randell EW, Zhai G.
Metabolomics. 2020 Apr 25;16(5):61. 

Metabolomics signature for non-responders to total joint replacement surgery in primary osteoarthritis patients: the Newfoundland Osteoarthritis Study.
Costello CA, Hu T, Liu M, Zhang W, Furey A, Fan Z, Rahman P, Randell EW, Zhai G.

J Orthop Res. 2020 Apr;38(4):793-802. 

 

 

Serum lysophosphatidylcholines to phosphatidylcholines ratio is associated with symptomatic responders to symptomatic drugs in knee osteoarthritis patients.
Zhai G, Pelletier JP, Liu M, Randell EW, Rahman P, Martel-Pelletier J.

Arthritis Res Ther. 2019 Nov 6;21(1):224. 

 

Activation of the phosphatidylcholine to lysophosphatidylcholine pathway is associated with osteoarthritis knee Cartilage volume loss over time.
Zhai G, Pelletier JP, Liu M, Aitken D, Randell E, Rahman P, Jones G, Martel-Pelletier J.

Sci Rep. 2019 Jul 4;9(1):9648. 

 

Alteration of Metabolic Pathways in Osteoarthritis.
Zhai G.

Metabolites. 2019 Jan 9;9(1):11. 

 

An evolutionary learning and network approach to identifying key metabolites for osteoarthritis.
Hu T, Oksanen K, Zhang W, Randell E, Furey A, Sun G, Zhai G.

PLoS Comput Biol. 2018 Mar 1;14(3):e1005986. 


Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility.
Zhai G, Randell EW, Rahman P.

Rheumatology (Oxford). 2018 Dec 1;57(12):2087-2095. 

 

 

 


Phospholipase A2 group 5 is a potential therapeutic target for osteoarthritis treatment.
Liu M, Furey A, Zhang W, Likhodi S, Randell E, Rahman P, Zhai G.
Arthritis & Rheumatology 69, 2017.

Non-responders to total joint replacement therapy in osteoarthritis patients and novel metabolic markers.
Zhai G, Liu M, Li Q, Furey A, Zhang W, Likhodi S, Randell E, Rahman P
Arthritis & Rheumatology 69, 2017.

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes.
Zhang W, Randell EW, Sun G, Likhodii S, Liu M, Furey A, Zhai G.
PLoS One. 2017 Sep 12;12(9):e0184105. 

Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis.

Zhang W, Sun G, Aitken D, Likhodii S, Liu M, Martin G, Furey A, Randell E, Rahman P, Jones G, Zhai G.
Rheumatology (Oxford). 2016 Sep;55(9):1566-74. 

Metabolomics differential correlation network analysis of osteoarthritis.
Hu T, Zhang W, Fan Z, Sun G, Likhodi S, Randell E, Zhai G.
Pac Symp Biocomput. 2016;21:120-31.

SMAD3 Is upregulated in human osteoarthritic cartilage independent of the promoter DNA methylation.
Aref-Eshghi E, Liu M, Razavi-Lopez SB, Hirasawa K, Harper PE, Martin G, Furey A, Green R, Sun G, Rahman P, Zhai G.
J Rheumatol. 2016 Feb;43(2):388-94. 

Genetic structure of the Newfoundland and Labrador population: founder effects modulate variability.
Zhai G, Zhou J, Woods MO, Green JS, Parfrey P, Rahman P, Green RC.
Eur J Hum Genet. 2016 Jul;24(7):1063-70. 

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis.
Aref-Eshghi E, Zhang Y, Liu M, Harper PE, Martin G, Furey A, Green R, Sun G, Rahman P, Zhai G.
BMC Musculoskelet Disord. 2015 Oct 9;16:287. 

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway.
Aref-Eshghi E, Liu M, Harper PE, Doré J, Martin G, Furey A, Green R, Rahman P, Zhai G.
Arthritis Res Ther. 2015 Sep 23;17:264. 

TGF-β signal transduction pathways and osteoarthritis.
Zhai G, Doré J, Rahman P.
Rheumatol Int. 2015 Aug;35(8):1283-92. 

Relationship between blood plasma and synovial fluid metabolite concentrations in patients with osteoarthritis.
Zhang W, Likhodii S, Aref-Eshghi E, Zhang Y, Harper PE, Randell E, Green R, Martin G, Furey A, Sun G, Rahman P, Zhai G.
J Rheumatol. 2015 May;42(5):859-65. 

Classification of osteoarthritis phenotypes by metabolomics analysis.
Zhang W, Likhodii S, Zhang Y, Aref-Eshghi E, Harper PE, Randell E, Green R, Martin G, Furey A, Sun G, Rahman P, Zhai G.
BMJ Open. 2014 Nov 19;4(11):e006286. 

SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.
Aref-Eshghi E, Zhang Y, Hart D, Valdes AM, Furey A, Martin G, Sun G, Rahman P, Arden N, Spector TD, Zhai G.
PLoS One. 2014 May 22;9(5):e97786.