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Melanie Seal

(Memorial) BSc (Hon), Dip Clin Epi, MD, FRCPC

Assistant Professor of Oncology (Medical Oncology)

Dr. H. Bliss Murphy Cancer Centre
300 Prince Philip Drive
St. John's, NL  A1B 3V6
t: (709) 777-7802
f: (709 777-8756

Dr. Melanie Seal MD FRCPC is a Medical Oncologist (Cancer Care Program) and Assistant Professor of Oncology (Faculty of Medicine, Memorial University) in St. John’s, Newfoundland.  She obtained a Doctor of Medicine degree and completed a residency in Internal Medicine at Memorial along with a Diploma in Clinical Epidemiology. She trained in Medical Oncology at McMaster University in Hamilton, Ontario and then undertook a breast cancer research fellowship at the BC Cancer Agency in Vancouver, British Columbia. She has a clinical and research interest in breast, gastrointestinal and central nervous system malignancies with ongoing projects in these sites. She is very involved with teaching and supervising research projects for medical trainees. She serves on many committees at the local and national level and is an active investigator for clinical trials.


Medical Oncologist, Cancer Care Program, Eastern Health. St. John’s, NL

Assistant Professor of Oncology, Faculty of Medicine, Memorial Univerisity of Newfoundland, St. John’s, NL


Breast Research Fellowship (Supervisor: Dr. Stephen Chia MD FRCPC), BC Cancer Agency, Vancouver, BC

Medical Oncology Residency (Royal College of Physicians and Surgeons of Canada certification).  McMaster University, Hamilton, ON

Internal Medicine Residency (Royal College of Physicians and Surgeons of Canada
certification).  Memorial University of Newfoundland, St. John’s, NL

Diploma in Clinical Epidemiology, Internal Medicine Residency.  Memorial University of
Newfoundland, St. John’s, NL

Doctor of Medicine.  Memorial University of Newfoundland, St. John’s, NL

Bachelor of Science (Honours – Neuroscience: Major – Biology).  Memorial University of
Newfoundland, St. John’s, NL


Lebert J, Lester R, Powell E, Seal MD, McCarthy J. Advances in the Systemic Treatment of Triple Negative Breast Cancer. Curr Oncol 2018 Jun; 25 (S1): S142-150

Ndikumana R, Taher A, Carp P, Seal MD. HER2 Overexpression and Amplification in Diffuse Gastric Cancer in Newfoundland and Labrador. Can J Pathol 2018 May; 10 (2): 39-46

Seal, MDSpring. J Clin Oncol.  2017 Mar 31

Morgan E, Norman A, Laing K and Seal M. Treatment and Outcome of Glioblastoma in Elderly versus Non-Elderly Patients: A Population-Based Study.  Curr Oncol. 2017 Apr 24(2):e92-98

Bosse D, Ng, T, Ahmad C, Alfakeeh A, Alruzug I, Biagi J, Brierley J, Chaudhury P, Cleary S, Colwell B, Cripps C, Dawson LA, Dorreen M, Ferland E, Galiatsatos P, Girard S, Gray S, Halwani F, Kopek N, Mahmud A, Martel G, Robillard L, Samson B, Seal MD, Siddiqui J, Sideris L, Snow S, Thirwell M, Vickers M, Goodwin R, Goel R, Hsu T, Tsvetkova E, Ward B, Asmis T.  Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016.  Curr Oncol 2017 Dec; 23(6):e605-614

Di Valentin T, Asmis T, Asselah J, Aubin F, Aucoin N, Berry S, Biagi J, Booth CM, Burkes R, Coburn N, Colwell B, Cripps C, Dawson LA, Dorreen M, Frechette D, Goel R, Gray S, Hammad N, Jonker D, Kavan Pi, Maroun J, Nanji S, Roberge D, Samson B, Seal MD, Shabana W, Simunovic M, Snow S, Tehfe M, Thirlwell M, Tsvetkova E, Vickers M, Vuong T and Goodwin R (2016).  Eastern Canadian Gastrointestinal Cancer Consensus Conference 2013: emerging therapies in the treatment of pancreatic, rectal and colorectal cancers.  Curr Oncol 2016 Feb 23(1):52-55

Morgan ER, Laing K, McCarthy J, McCrate F, Seal MD. Using tablet-based technology in patient education about systemic therapy options for early stage breast cancer: a pilot study.  Curr Oncol. 2015 Oct 22(5):364-369

Murphy L, McCarthy J, McCrate F, Laing K, Powell E, Seal MD, Edwards S.  Use of bisphosphonates in metastatic breast cancer: single institution review at the Dr. H. Bliss Murphy Cancer Centre.  Support Care Cancer. 2013 Jun 21(6):1557-1560

Seal MD, Speers CH, O’Reilly S, Gelmon KA, Ellard S, Chia SK.  Outcomes of women with early stage breast cancer receiving adjuvant trastuzumab.  Curr Oncol. 2012 Aug 19(4):197-201

McFarlane R, Seal MD , Speers C, Woods R, Masoudi H, Aparicio S, Chia SK.  Molecular alterations between primary breast cancer and the subsequent locoregional/metastatic tumor. Oncologist. 2012 17(2):172-178

Seal MD, Pond GR, Wilkieson TJ, Hotte SJ.  Effect of geographic distance from a cancer centre on choice of systemic therapy in metastatic colorectal cancer. Oncology Exchange. 2011 Aug 10(3):8-12

Armstrong D, Powell E, Seal MD, Rorke S, Laing K, Ganguly P, Pochini C, McCrate F, McCarthy J.  Nasopharyngeal cancer in Newfoundland and Labrador: 7-year experience. Oncology Exchange. 2011 May 10(2):e4-7

Seal MD and Chia SK.  Challenging the dogma on trastuzumab: a matter of the heart. Lancet. 2010 Jan 30; 375(9712):349-50

Seal MD and Chia SK.  What is the difference between triple-negative and basal breast cancers? Cancer J. 2010 Jan-Feb 16(1):12-16

Seal MD, Wilson C, Naus GJ, Chia SK, Bainbridge TC, Hayes MM.  Encapsulated apocrine papillary carcinoma – a tumour of uncertain malignant potential: report of five cases. Virchows Arch. 2009 Dec 455(6):477-483

Why don’t BRCA carriers in NL receive adequate cancer screening and prevention?
Source: Newfoundland and Labrador (NL) SUPPORT Patient-Oriented Research Grant    ($ 75, 000).  Dates of Approved Project: 2017-2018.  PI: Dawson L.  Role: Co-Investigator                                   

Impact of sleep on cancer related cognitive dysfunction in women with breast cancer.  Source:  Memorial University of Newfoundland Seed, Bridge, and Multidisciplinary Fund, ($10,000).  Dates of Approved Project:  2016-2018.  Name of P.I.: Garland SN.  Role: Co-applicant  

The assessment of genome wide changes between the primary tumour and the relapsed metastatic tumour with array CGH.  Source: Canadian Breast Cancer Foundation BC/Yukon Chapter, Dollar ($102,500).  Dates of Approved Project: 2008-2010.  PI: Chia SK.  Role: Co-applicant


Physician Lead Clinical Practice Guideline: Treatment of Borderline Resectable and Locally
Advanced Pancreatic Cancer, June 24, 2014

Physician Lead Clinical Practice Guideline: Staging of Primary Breast Cancer, May 23, 2012
Copyright © 2018 Memorial University of Newfoundland.   Newfoundland and Labrador, Canada.