Recent relevant peer-reviewed publications:
K.J. Brymer*, J.R. Barnes*, M.P. Parsons (2021). Entering a new era of quantifying glutamate clearance in health and disease. Journal of Neuroscience Research. Accepted Feb 2021.
M.O. Quartey, J.N.K. Nyarko, J.M. Maley, J.R. Barnes*, M.A.C. Bolanos, R.M. Heistad, K.J. Knudsen, P.R. Pennington, J. Buttigieg, C.E. De Carvalho, S.C. Leary, M.P. Parsons, D.D Mousseau (2021). The Aβ(1-38) peptide is a negative regulator of the Aβ(1-42) peptide implicated in Alzheimer disease progression. Scientific Reports. 11(1):431. doi: 10.1038/s41598-020-80164-w.
C.M. Wilkie*, J.R. Barnes*, C.L. Benson*, K.J. Brymer*, F. Nafar*, M.P. Parsons (2020) Hippocampal synaptic dysfunction in a mouse model of Huntington disease is not alleviated by ceftriaxone treatment. eNeuro. 7(3):ENEURO.0440-19.2020. doi: 10.1523/ENEURO.0440-19.2020.
J.R. Barnes*, B. Mukherjee*, B.C. Rogers*, F. Nafar*, M. Gosse*, M.P. Parsons (2020). The relationship between glutamate dynamics and activity-dependent synaptic plasticity. The Journal of Neuroscience. 40(14): 2793-2807.
V. Linehan, L.Z. Fang, M.P. Parsons, M. Hirasawa (2020) High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus. Molecular Metabolism. 36:100977. doi: 10.1016/j.molmet.2020.100977.
J.G. Quirion*, M.P. Parsons (2019). The onset and progression of hippocampal synaptic plasticity deficits in the Q175FDN mouse model of Huntington disease. Frontiers in Cellular Neuroscience. Jul 17;13:326. doi: 10.3389/fncel.2019.00326
N.F. Pinky*, C.W. Wilkie*, J.R. Barnes*, M.P. Parsons (2018). Region- and activity-dependent regulation of extracellular glutamate. The Journal of Neuroscience. 38(23):5351-5366.
A.L. Southwell, H.B. Kordasiewicz, D. Langbehn, N.H. Skotte, M.P. Parsons, E.B. Villanueva, N.S. Caron, M.E. Østergaard, L.M. Anderson, Y. Xie, L.D. Cengio, H. Findlay-Black, C.N. Doty, B. Fitsimmons, E.E. Swayze, P.P. Seth, L.A. Raymond, F. Bennett, M.R. Hayden (2018). Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease. Science Translational Medicine. 10(461) S. Sanders, M.P. Parsons, K. Mui, A.L. Southwell, S. Franciosi, D. Cheung, S. Waltl, L.A. Raymond, M.R. Hayden (2016). Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice. BMC Biology. 14(1):108.
A.L. Southwell, A. Smith-Dijak, C. Kay, M. Sepers, E.B. Villanueva, M.P. Parsons, Y. Xie, L. Anderson, B. Felczak, S. Waltl, S. Ko, D. Cheung, L. Dal Cengio, R. Slama, E. Petoukhov, L.A. Raymond, M.R Hayden (2016). An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes. Hum. Mol. Genet. 25(17):3654-3675
M.P. Parsons, M.P. Vanni, R. Kang, C. Woodard, T.H. Murphy, L.A. Raymond (2016). Real-time imaging of glutamate clearance challenges an established view of excitotoxicity in Huntington disease. Nature Communications. 7:11251 doi: 10.1038/ncomms11251.
C. Buren*, M.P. Parsons*, A. Smith-Dijak, L.A. Raymond *Equal Contribution (2016). Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington disease.
Neurobiology of Disease. 87:80-90
C. Buren, G. Tu, M.P. Parsons, M.P. Sepers, L.A. Raymond (2016). Influence of cortical synaptic input on striatal neuronal excitability and sensitivity to excitotoxicity in corticostriatal co-culture. J. Neurophys. 116(2):380-90.
M.P. Parsons and L.A. Raymond (2014). Extrasynaptic NMDA receptor involvement in central nervous system disorders. Neuron. 82(2):279-93 (review)
K. Kolodziejczyk, M.P. Parsons, A.L Southwell, M.R. Hayden, L.A. Raymond (2014). Striatal synaptic dysfunction and hippocampal plasticity deficits in the hu97/18 mouse model of Huntington disease. PloS One. 9(4):e94562
M.P. Parsons, Rujun Kang, Shaun S. Sanders, Michael R. Hayden, Lynn A. Raymond (2014). Bidirectional control of PSD-95 by non-pathologic huntingtin. J. Biol. Chem. 289(6):3518-28
A.J. Milnerwood*, M.P. Parsons*, Fiona B. Young, Roshni Singaraja, Sonia Franciosi, Michael R. Hayden, Lynn A. Raymond (2013). Memory and synaptic deficits in Hip14/DHHC17 knockout mice. Proc. Natl. Acad. Sci. USA 10(50):20296-301 *Equal contribution
Book Chapter:
Parsons MP and Raymond LA. Chapter 21: Huntington Disease. Neurobiology of Brain Disorders. Elsevier. 2015.
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