News at Medicine - July 2014 - New publication by neuroscience grad student

New publication by neuroscience grad student
July 15, 2014
Brian Roome, a recent graduate student from Dr. Jacqueline Vanderluit’s laboratory, is author of the paper titled A reproducible Endothelin-1 model of forelimb motor cortex stroke in the mouse, published in the Aug. 15 issue of the Journal of Neuroscience Methods. This work is based on his M.Sc. thesis in neuroscience in the Faculty of Medicine.
In his research project, Mr. Roome developed a model of focal stroke in the mouse. A model of stroke in mice that is clinically comparable to human stroke was lacking. This limited researchers from taking advantage of the numerous transgenic mouse lines currently available to identify potential genetic targets to promote neural repair. By developing a reproducible model of focal stroke in mice with measureable behavioural deficits, Mr. Roome has generated a tool that can be used to test future regenerative therapies.  

The stroke model was imported to mice, based on Dr. Dale Corbett’s work using Endothelin-1 in rats. Endothelin-1 is a potent vasoconstrictor which causes a stroke near the site of injection. In addition, Mr. Roome developed a more sensitive analysis of a behavioural test to measure motor deficits in the mouse’s forelimbs following stroke. Prior to this study, there was indecision as to whether Endothelin-1 could generate a reproducible stroke with consistent behavioural deficits in mice. Mr. Roome’s findings have demonstrated that Endothelin-1 can produce a small, clinically relevant stroke model in mice which can be used to analyze neural repair strategies. 
Mr. Roome, originally from Grand Falls-Windsor, has recently been accepted in the PhD program in neuroscience at McGill University where he will be starting in September in the laboratory of Dr. Artur Kania.