Please Enter a Search Term
Division of BioMedical Sciences

Our People - Faculty Websites

Click here for a complete listing of peer-reviewed publications

Select peer-reviewed publications:      

  1. Holland SJ, Berghuis LM, King JJ, Iyer L, Sikora K, Fifield H, Peter S, Quinlan EM, Fumiaki S, Prashant S, Trancoso I, Iwanami N, Temereva E, Strohmeier C, Kuratani S, Venkatesh B, Evanno G, Aravind L, Schorpp M, Larijani M*, Boehm T*. Expansions, diversification and inter-individual copy number variation of AID/APOBEC family cytidine deaminase genes in lampreys. Proc Natl Acad Sci, 2018. Mar 19. pii: 201720871 (*co-senior authors)
  2. Methot SP, Ludivine LC, Poorani SG, Eranki AK, Fifield H, Patenaude AM, Gilmore J, Bagci H, Cote JF, Larijani M, Verdun RE, Di Noia JM. A checkpoint for AID at the chromatin promotes selective tethering to elongating RNAPII to license mutagenesis. Nature Comm. 2018. March 10.1038/s41467-018-03387-6
  3. Yoshioka E, Chelakkot VS, Licursi M, Rutihinda S, Som J, Derwish L, King JJ, Pongopparat T, Mearow K, Larijani M, Dorward AM, Hirasawa K. Enhancement of Cancer-Specific Protoporphyrin IX Fluorescence by Targeting Oncogenic Ras/MEK Pathway. Theranostics. 2018. In press
  4. Borzooee F, Asgharpour M., Quinlan E., Grant M., Larijani M. Viral subversion of APOBEC3s: lessons for anti-tumor immunity and tumor immunotherapy.  International Rev. Immunol. 2017. Dec 6:1-14. doi: 10.1080/08830185
  5. Abdouni H, King JJ, Ghorbani A, Fifield H, Berghuis L, Larijani M. DNA/RNA hybrids structures modulate the catalytic activity of purified AID. Mol. Immunology 2017. 2017 Nov 18;93:94-106
  6. Quinlan EM, King JJ, Amemiya CT, Hsu E, Larijani M. Biochemical regulatory features of AID have remained conserved from lamprey to humans. Mol Cell. Biol.2017. Jul 17. pii: MCB.00077-17
  7. Grant M, Larijani M. Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes. AIDS Research and Therapy. 2017. 2017 Sep 12;14(1):44
  8. King JJ, Larijani M. A novel regulator of AID/APOBECs: Schrödinger's CATalytic pocket, Frontiers Imm. 2017, Apr 6;8:351.
  9. King JJ, Manuel CA, Barrett CV, Raber S, Lucas HM, Sutter P, Larijani M. Catalytic pocket inaccessibility of activation induced cytidine deaminases a safeguard against excessive mutagenic activity, Structure. 2015. Apr 7; 23(4):615-27
  10. Squires K, Monajemi M, Woodworth CF, Grant MD, Larijani, M. Impact of APOBEC mutations on CD8+ T cells recognition of HIV epitopes varies depending on the restricting HLA. JAIDS. 2015, Oct 1;70(2):172-8
  11. Kolypetri P, King J, Larijani M, Carayanniotis G. Genes and environment as predisposing factors in autoimmunity: acceleration of spontaneous thyroiditis by dietary iodide in NOD.H2h4 mice. International Rev. Immunol. 2015. Aug 19; 1-15
  12. Monajemi M, Woodworth CF, Zipperlen K, Gallant M, Grant MD, Larijani M. Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells. PLOS ONE. 2014. Apr 10; 9(4):93428
  13. Zahn A, Eranki AK, Patenaude AM, Methot SP, Fifield H, Cortizas EM, Foster P, Imai K, Durandy A, Larijani M, Verdun RE, Di Noia JM.  Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair in class switch recombination. PNAS.2014. Mar 18; 111(11):E988-97
  14. Abdouni H, King J, Suliman Mw, Quinlan M, Fifield H, Larijani M. Zebrafish AID is capable of deaminating methylated deoxycytidines. Nucleic Acids Research. 2013.1; 41(10):5457-68.
  15. Abdelfatah N, McComiskey D, Griffin A, Moore S, Negrijn C, Hodgkinson K, King J, Larijani M, Houston J, Doucette L, Stanton S, Young T. Identification of a novel in-frame deletion in KCNQ4 (DFNA2A) and a convincing case of phenocopies in a multiplex family with variable ADSNHL. Eur J Hum Genet. 2013.Oct; 21(10):1112-9.
  16. Martin A, Larijani M. The Biochemistry of Activation-Induced Deaminase and its physiological functions. Seminars in Immunology. 2012. Aug; 24(4):255-63.
  17. Monajemi M, Woodworth C, Benkaroun J, Grant M, Larijani M. Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.  Retrovirology. 2012 Apr 30; 9(1):35.
  18. Dancyger A, King J, Quinlan M, Fifield H, Tucker S, Saunders H, Berru M, Magor B, Martin A, Larijani M. Differences in the enzymatic efficiency of bony fish and human AID are mediated by a single residue in the C-terminus that modulates single-stranded DNA binding. FASEB J. 2012. Apr; 26(4):1517-25.
  19. Fritz JH, Rojas O, Simard N, McCarthy D, Hapfelmeier S, Rubino S, Robertson S, Larijani M, Gosselin J, Ivanov I, Martin A, Casellas R, Philpott D, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, and Gommerman JL. Acquisition of a multifunctional TNFa/iNOS-producing IgA+ plasma cell phenotype in the gut. Nature. 2011.481(7380):199-203.
  20. Duvvuri B, Duvvuri VR, Grigull J, Martin A, Pan-Hammerstrom Q, Wu GE, Larijani M. Altered spectrum of somatic hypermutation in Common Variable Immunodeficiency Disease characteristic of defective repair of mutations. Immunogenetics.2011. 63(1):1-11.
  21. Frieder D, Larijani M, Collins C, Shulman M, Martin A. The concerted action of MSH2 and UNG stimulates error-prone repair at A:T basepairs in hyper mutating B cells. Mol Cell. Biol.2009. (18):5148-57.
  22. Larijani M and Martin A. ssDNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. Mol Cell. Biol.2007. (23):8038-8048.
  23. Larijani M, Petrov A, Kolenchenko O, Berru M, Krylov S, Martin A.  AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner. Mol Cell. Biol.2007. (27): 20-30.
  24. Frieder D, Larijani M, Tang E, Parsa JY, Basit W, Martin A.  Antibody diversification: mutational mechanisms and oncogenesis. Immunol. Res.2006. 35(1-2):75-88.
  25. Larijani M, Chen S, Cunningham LA, Volpe JM, Cowell LG, Lewis SM, Wu GE. The recombination difference between mouse kappa and lambda segments is mediated by a pair-wise regulation mechanism. MolImmunol. 2006. 43(7):870-81.
  26. Larijani M, Zaheen A, Frieder D, Wang Y, Wu GE, Edelmann W, Martin A. Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events. Nucleic Acids Res.2005. 33(21):6733-42.
  27. Yuan SW, Agard E, Larijani M, Wu GE. Coding joint diversity in mature and immature B cell lines.  Scand. Journal of Immunol. 2005. 62 Suppl 1:114-8.
  28. Larijani M, Frieder D, Sonbuchner TM, Bransteitter R, Goodman MF, Bouhassira EE, Scharff MD, Martin A.  Methylation protects cytidines from AID-mediated deamination.
    MolImmunol. 2005. 42(5):599-604.
  29. Larijani M, Frieder D, Basit W, Martin A. The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung(-/-)msh2(-/-) mice. Immunogenetics.2005. 56(11):840-5.
  30. Golub R, Andre S, Hassanin A, Affaticati P, Larijani M, Fellah JS.  Early expression of two TdT isoforms in the hematopoietic system of the Mexican axolotl. Implications for the evolutionary origin of the N-nucleotide addition.  Immunogenetics.2004. 56(3):204-13.
  31. Montalbano A, Ogwaro KM, Tang A, Matthews AGW, Larijani M, Oettinger MA, Feeney AJ. V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J. Immunol. 2003. 171(10):5296-304.
  32. Hirano SL, Tornberg UC, Larijani M, Holmberg D, Cazenave PA, Wu GE.  Identity of IGHV-7183.1 (V81x) coding and recombination signal sequences among wild-derived mice.  Immunogenetics.2001.53(1):54-8.
  33. Larijani M, Yu CC, Golub R, Lam QL, Wu GE. The role of components of recombination signal sequences in immunoglobulin gene segment usage: a V81x model. Nucleic Acids Res. 1999. 1;27(11):2304-9.
  34. Larijani M, Yu CCK, Miljanic IN, Wu GE. Differential usage of VH gene segments is mediated by cis elements. J Immunol. 1998. 1;161(7):3444-54.
  35. Zhang XL, Seong R, Piracha R, Larijani M, Heeney M, Parnes JR, Chamberlain JW. Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development. J. Immunol.1998. 1;161(5):2254-66.

Go Back
Copyright © 2018 Memorial University of Newfoundland.   Newfoundland and Labrador, Canada.