Immunopathology Slides

K-IM 1

Acute asthma.  The lumen of the bronchiole is occluded by mucus (right upper of photo).

K-IM 2

Curschmann's spiral found in a case of acute asthma spirals are whorls of desquamated or shed respiratory epithelial cells contained in mucous plugs as seen in sputum.

K-IM 3

Acute asthma.  Note the marked thickening of the basement membrane of bronchioles.

K-IM 4

Acute asthma.  Bronchiolar wall contains an infiltrate of inflammatory cells including eosinophils.

K-IM 5

Case of erythroblastosis fetalis.  Note marked tissue edema.

K-IM 6

Extramedullary hemopoiesis in erythroblastosis fetalis.  Note foci of hemopoietic cells within liver sinusoids.

K-IM 7

Acute contact dermatitis showing erythematous area of skin reaction.

K-IM 8

Blister formation in acute contact dermatitis.

K-IM 9

Acute contact dermatitis showing marked edematous changes within the epidermis.

K-IM 10

Systemic sclerosis.  Atrophy and stiffness of hands due to deposition of dermal collagen.

K-IM 11

Early stages of systemic sclerosis showing marked edematous changes within the dermis of skin.

K-IM 12

Grave's disease.  Note the hyperplasia of follicles associated with a lymphoid infiltrate (with germinal centre formation) in the interfollicular region.  Scanty colloid in follicles.

K-IM 13

Gross of thyroid in Hashimoto's thyroiditis.  Note pale grey nodular cut surface.

K-IM 14

Hashimoto's thyroiditis.  Intense lymphocytic infiltrate with destruction of follicles.  Some degenerating follicles are lined by cells with eosinophilic cytoplasm (Hurthle cells).

K-IM 15 and 16

Systemic lupus erythematosis.  Erythematous rash on face, chest and arms.

K-IM 17

Systemic lupus erythematosis.  LE Bodies.  Formed by combination of antibodies with leucocyte nuclear DNA.  The resultant complex is engulfed by neutrophils or macrophages.

K-IM 18

Systemic lupus erythematosis.  Marked thickening of capillary walls within glomeruli due to immune complex deposition.

K-IM 19

Systemic lupus erythematosis.  Electron micrograph showing subendothelial deposition of immune complexes.

K-IM 20 and 21

Rheumatoid arthritis.  Narrowing of metacarpal - phangeal joint space with ulnar deviation.

K-IM 22 and 23

Synovial biopsy in case of rheumatoid arthritis.  Proliferation of synovial cells with villous formation.  Intense infiltrate of lymphocytes within synovium.

K-IM 24

Renal biopsy in Goodpasture's syndrome.  Proliferative glomerulonephritis with epithelial crescent formation within Bowman's space.

K-IM 25

Goodpasture's syndrome.  Immunofluorescence showing linear deposition of IgG along glomerular basement membrane.

K-IM 26

Goodpasture's syndrome.  Marked hemorrhage in alveolar spaces of lung.

K-IM 27

Goodpasture's syndrome.  Immunofluorescence showing linear deposition of IgG along alveolar basement membranes.

K-IM 28

Grave's disease showing exophthalmos.

K-IM 29 and 30

Kaposi's sarcoma in case of AIDS.  Pleomorphic spindle cells within dermis surround cleft-like spaces containing red cells.  Irregular blood vessels lined by plump endothelial cells are also present.

K-IM 31

Pneumocystis carinii in case of AIDS.  Special silver stain shows the intra-alveolar location of small cyst-like organisms some of which contain a prominent central dot.

K-IM 32 and 33

Lung cytomegalovirus infection in case of AIDS.  Note the dense basophilic intranuclear inclusions within alveolar lining cells.  Some inclusions are surrounded by a thin pale halo.

K-IM 34

Case of severe combined immunodeficiency disease.  Note the absence of the normal thymic shadow on chest x-ray.

K-IM 35

Thymus gland in a case of severe combined immunodeficiency disease.  Microscopy shows a primitive structure devoid of lymphoid cells and Hassall's corpuscules.

K-IM 36

Case of severe combined immunodeficiency disease. Pneumocystis carinii infection in lung.

K-IM 37

Case of severe combined immunodeficiency disease. Cytomegalovirus infection in lung.

K-IM 38

Normal thymus.

K-IM 39

Case of chronic granulomatous disease with skin abscess formation.

K-IM 40

Case of chronic granulomatous disease showing marked stricture of the gastric antrum following infection and granulation tissue formation.