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Rod Russell

BioMedical Sciences
Ph.D. McGill University

Associate Professor of Immunology and Infectious Diseases

Division of BioMedical Sciences
Faculty of Medicine
Memorial University of Newfoundland
Health Sciences Centre
Office: HSC-1815  Lab:  HSC-1809
300 Prince Philip Drive
St. John's, NL
CANADA   A1B 3V6



Phone: 709-777-8974
Fax: 709-777-8294

rodney.russell@med.mun.ca

DAPI
CD81

DAPI
HCV

DAPI
CD81
HCV

Check out Russell Lab on facebook



Research Interests:


Molecular Virology
Drug Targets and Discovery
Viral Immunology
 

Research Program:

Molecular Biology of Hepatitis C Virus
 

Projects:

The Role of HCV p7 in the Viral Life Cycle
Viral Determinants of HCV Assembly
Analysis of Drug Resistant Hepatitis C Viruses
Mechanisms of Apoptosis in HCV-Infected Cells
Exosomes: Social Networking for Cells


Current Personnel:
  

Ali Atoom (PhD Student [2008-present]; Funded by CIHR/RPP)
Megan Conway (Research Assistant I [2011-present])
Hassan Kofahi (PhD Student funded by the Jordanian Government [2011-present]; Co-Supervised by Dr. Michael Grant)
Nate Taylor (Summer Student [2012] and now MSc Student [2012-present]; Funded by NCRTP)


Alumni:


Adam Legge (Medicine Summer Student funded by MED SURA [2013]; currently in MUN Medical School)
Dr. Dan Jones (Postdoc funded by NCRTP and CIHR [2010-2013]; currently a Postdoc at Oxford)
Heidi Morris (Summer Student funded by NSERC USRA [2009] and MED SURA [2010], then MSc Student funded by Dean’s Fellowship and CIHR [2010-2013]; currently a PhD Student at Harvard)
Kayla Holder (Summer Student [2010] and MSc Student funded by NCRTP and CIHR [2011-2013]; co-supervised by Dr. Michael Grant)
Chelsea Ash (Summer Student declined MED SURA, funded by NCRTP [2012 and 2013], then Honour’s Student; currently in MUN Medical School)
Nicole Whittle (Research Assistant II [2008-2009 and 2010-2011]; currently the owner of Le Boudoir)
Megan Powdrill (Visiting PhD Student from McGill University; NCRTP Elective [2011])
Eugenia Khorochkov (Medicine Summer Student funded by MED SURA [2011]; currently at the London Health Sciences Centre)
Sarah Welbourne (Visiting PhD Student from McGill University; NCRTP Elective [2009])
Maria Brazil (Summer Student declined MED SURA, funded by NCRTP [2010]; currently in MUN Medical School)
Candice Jackel-Cram (Visiting PhD Student from University of Saskatchewan; NCRTP Elective [2008])
Natasha Hollett (Research Assistant II [2008-09]; currently a Research Assistant at the University of Manitoba)
Ryan Caines (Regional Science Fair Student [2010 and 2011])
Ben Sheih (Medicine Summer Student funded by MED SURA [2008]; currently a Medical Doctor)
Heather Hollett (Summer and MUCEP Student [2008]; currently a Teacher



Lab Photos:

 

Dr. Rodney Russell and Nicole Whittle Nicole Whittle and Natasha Noel
 
Natasha Noel Dr. Rodney Russell and Natasha Noel
 
Nicole Whittle and Heather Hollett Nicole Whittle and Natasha Noel
 
L-R:  Heather Hollett, Natasha Noel, Rod Russell,
Nicole Whittle, and Ben Shieh
 Ali Atoom
 

L-R: Ali Atoom (PhD student), Rod Russell (Supervisor),
Dan Jones (Postdoc), and Nicole Whittle (Research Assistant)

L-R:  Nicole Whittle (RAII), Dr. Dan Jones (Postdoc), Heidi Morris (MSc Student),
Dr. Rod Russell, Kayla Harris (MSc Student), Alit Atoom (PhD Student)

L-R:  Ali Atoom (PhD Student), Heidi Morris (MSc Student), Dr. Dan Jones (Postdoc), Dr. Rod Russell, Kayla Harris (MSc Student), Nicole Whittle (RAII)

 L-R: Ali Atoom (PhD Student), Dr. Rod Russell (Grand Pooba), Chelsea Ash (Honour’s Student), Megan Conway (Research Assistant), Dr. Dan Jones (Postdoc), Kayla Holder (MSc Student), Nate Taylor (MSc Student), Adam Legge (Medical Student)
 
L-R: Dr. Rod Russell (El Heffe), Adam Legge (Medical Student), Nate Taylor (MSc Student), Heidi Morris (MSc Student), Megan Conway (Research Assistant),
Hassan Kofahi (PhD Student)
 

Selected Publications:

Holder K, Stapleton SN, Gallant ME, Russell RS*, Grant MD*. Hepatitis C virus-infected cells down-regulate NKp30 and inhibit ex vivo natural killer cell functions. J Immunol. 2013 191(6):3308-18.

Singaravelu R, Chen R, Lyn RK, Jones DM, Rouleau Y, O’Hara S, Cheng J, Srinivasan P, Nasheri N, Russell RS, Tyrrell DL, Pezacki JP. Hepatitis C virus induced up-regulation of microRNA-27: A novel mechanism of hepatic steatosis. Hepatology. 2013 Jul 29.

Atoom AM, Jones DM, Russell RS*. Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production. Virus Res. 2013 176(1-2):199-210.

Steenbergen RHG, Joyce M, Thomas BS, Jones DM, Law J, Russell RS, Pezacki J, Houghton M, Tyrrell L. Human serum leads to differentiation of hepatoma cells and a 1000-fold increase in HCV JFH-1 titers. Hepatology. 2013 Jun 14.

Zhang X, Daucher M, Armistead D, Russell RS, Kottilil S. MicroRNA expression profiling in HCV-infected human hepatoma cells identifies potential anti-viral targets induced by Interferon-lambda. PLoS ONE. 2013;8(2):e55733.

Kohli A, Zhang X, Yang J, Russell RS, Donnelly R, Young H, Imamichi T, Lempicki RA, Masur H, Kottilil S. Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and non-infected hepatoma cells. J Viral Hepat. 2012 19(12):843-53.

Sarhan MA, Chen AY, Russell RS, Michalak TI. Wild-type hepatitis C virus and HCV JFH-1 clones contrastingly differ in their ability to infect human lymphocyte and hepatoma cells. J Gen Virol. 2012 Epub Aug 1. 93(Pt 11):2399-407.

Zhang X, Daucher M, Baeza J, Kim CW, Russell RS, Kottilil S. Human immunodeficiency virus enhances hepatitis C virus replication through the differential regulation of IFN and TGF family genes. J Med Virol. 2012 84(9):1344-52.

Powdrill MH, Tchesnokov EP, Kozak RA, Russell RS, Martin R, Svarovskaia ES, Mo H, Kouyos RD, Götte M. 2011. Contribution of mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance. PNAS. 108(51):20509-13. Epub 2011 Dec 1.

Jones DM, Atoom AM, Zhang X, Kottilil S, Russell RS*. 2011. A genetic interaction between the core and NS3 proteins of hepatitis C virus is essential for production of infection virus. J Virol. 85(23):12351-61. Epub 2011 Sep 28.

Liang H, Russell RS, Yonkers NL, McDonald D, Rodriguez B, Harding CV, Anthony DD. 2009. Differential effect of JFH1 HCV on human MDC and PDC function. J Virol. 83(11):5693-707.