Ph.D. University of British Columbia
Associate Professor of Neurosciences
Division of BioMedical Sciences
Faculty of Medicine
Memorial University of Newfoundland
300 Prince Phillip Drive
St. John’s, NL, Canada, A1B 3V6
Phone: 709-777-8926 (office)
|Current Lab Members:
|Robert Bartlett, BSc
Lauren Fogarty, BSc
SM Mahmudul Hasan, BSc, MSc
R.Brian Roome, BSc, MSc
Jieying Xiong, BSc, MSc
Laboratory technician (part-time)
Laboratory manager (part-time)
|Beibei Song, BSc
Hiliary Martin, BSc
Kristine Day, MSc, RA
Ashley Sheen, BSc
Craig Malone, MSc
Angela Power, BSc
Michael Furlong, BSc
Waleed Abdel-Razek, BSc
Grants Facilitation Officer, (Memorial)
Stem cells and neurogenesis in the developing and adult mammalian brain.
Neural stem cells generate the building blocks of the brain, therefore identifying the factors that regulate their numbers is essential for understanding their role in developmental disorders, cancer and regeneration. The discovery of stem cells in the adult mammalian brain has directed research towards stem cell based regeneration strategies. As a result of the paucity of endogenous stem cells within the adult brain, much research has been focussed on stem cell transplantation and strategies to expand the stem cell population. Since neural stem cell numbers are maintained by a balance between proliferation and cell death, my laboratory is exploring strategies to promote neural stem cell survival within the endogenous stem cell population and in transplanted populations to ultimately explore their therapeutic potential.
||Identify the biological function of Mcl1 in regulating neural stem cell survival and neural regeneration.
||Identify the mechanisms which regulate survival of neural stems in the developing mammalian brain.
||Manipulate the expression of survival-promoting Bcl-2 family members to promote neural regeneration following an ischemic insult.
||Identify the BH3-only Bcl-2 family members that are necessary to initiate neural stem cell apoptosis.
Canadian Institutes of Health Research
Canadian Foundation of Innovation – Leadership Opportunity Fund
Heart and Stroke Foundation of Canada – Centre for Stroke Recovery – Catalyst Grant
Research and Development Corporation of Newfoundland and Labrador
Medical Research Fund, Memorial University
Selected Peer-Reviewed Publications:
Hasan SMM, Sheen A, Power AM, Langevin LM, Xiong J, Furlong M, Day K, Schuurmans C, Opferman JT, Vanderluit JL. (2013) Mcl-1 regulates terminal mitosis of neural precursor cells in the mammalian brain. Development 140(15): 3118-3127.
Malone CD, Hasan SMM, Power AM, Sheen A, Xiong J, Furlong M, Opferman JT, Vanderluit JL. (2012) Mcl-1 is a survival factor for neural stem cells in the embryonic and adult mammalian brain. Molecular and Cellular Neuroscience. 49:439-447.
Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS, Opferman JT, Slack RS. (2011) Mcl-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO Journal. 30(2):395-407.
McClellan KA*, Vanderluit JL*, Julian LM, Andrusiak MG, Dugal-Tessier D, Park DS, Slack RS. (2009). P107/E2F regulates FGF2-mediated proliferation of neural progenitor cells. (*equal contributions) Molecular and Cellular Biology, 29(17):4701-4713.
Arbour NA*, Vanderluit JL*, Legrand JN, Jahani-asl A, Cheung ECC, Kelly, M, MacKenzie AE, Park DS, Opferman JT, Slack RS. (2008) Mcl-1 is a key regulator of apoptosis in neural precursor cells and following acute neuronal injury in vitro. (*equal contributions). Journal of Neuroscience 28:6068-6078.
Vanderluit JL, Wylie CA, McClellan KA, Ghanem N, Fortin A, Callaghan S, Park DS, Slack RS. (2007) The Retinoblastoma family member, p107 regulates the rate of progenitor commitment to a neuronal fate. Journal of Cell Biology , 178(1):129-139.
Keramaris E, Vanderluit JL, Bahadori M, Mousavi K, Davis RJ, Flavell R, Slack RS, Park DS. (2005) c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. Journal of Biological Chemistry. 280(2):1132-41.
Vanderluit JL, Ferguson KL, Nikoletopoulou V, Parker MH, Ruzhynsky V, Alexson T, McNamara SM, Park DS, Rudnicki M, Slack RS. (2004) P107 regulates neural precursor cells in the mammalian brain. Journal of Cell Biology 116:853-863.
Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. (2004) Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell. 5(6):539-51.
Vanderluit, JL, McPhail, LT, Kobayashi, NR, Fernandes, KJL, Tetzlaff, W. (2003) In vivo application of mitochondrial inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons. Cell Death and Differentiation. 10:969-976.
Ferguson, KL, Vanderluit, JL, Hebert, JM, McIntosh, WC, Tibbo, E, MacLaurin, JG, Park, DS, Wallace, VA, Vooijs, M, McConnell, SK, Slack, RS (2002) Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO Journal, 21(13):3337-3346.
Vanderluit, JL, McPhail, LT, Fernandes, KJL, McBride, CB, Huguenot, C, Roy, S, Robertson, GS, Nicholson, DW, Tetzlaff, W. (2000) Caspase-3 is developmentally regulated in facial motoneurons and activated following axotomy in neonatal rodents but is ultimately not required for cell death. European Journal of Neuroscience, 12:3469-3480
Vanderluit, JL, Bourque, J, Peterson, A, Tetzlaff, W. (2000) Demyelination of the dorsal columns by photablation of oligodendrocytes in transgenic mice. Journal of Neuroscience Research. 62:28-39.