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FACULTY OF MEDICINE
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Christopher Kovacs

Medicine
M.D., B.A. Queen's, FRCPC, FACP, FACE

Professor of Medicine (Endocrinology)

Room: H5309

709-777-6881

ckovacs@mun.ca

Dr. Christopher Kovacs obtained his MD and trained in Internal Medicine at Queen’s University, and did his clinical fellowship in Endocrinology and Metabolism at the University of Alberta.  He did a postdoctoral research fellowship in bone and mineral metabolism at Harvard Medical School and Massachusetts General Hospital. During a sabbatical he studied bone histomorphometry at St. Vincent’s Institute of the University of Melbourne.

His clinical practice focuses on osteoporosis, disorders of bone metabolism, thyroid disorders, and general endocrinology. His basic and translational research focuses on adaptations in calcium and bone metabolism that occur during reproduction and fetal development. 

He has received over a dozen national and international awards for excellence in research, including the 2003 Gold Medal in Medicine from the Royal College of Physicians and Surgeons of Canada; the 2003 Young Investigator Award from the Canadian Society of Endocrinology and Metabolism, and Young Investigator Awards from the American Society for Bone and Mineral Research and Advances in Mineral Metabolism. He has served on Editorial Boards of journals, CIHR and NIH grant committees, and as a reviewer for grant agencies in Canada, USA, England, Ireland, and Australia. He was also on the Institute of Medicine / National Academies of Science USA Committee to Review Calcium and Vitamin D. He is the president of Advances in Mineral Metabolism for 2015-2017.

Since 2000 his graduate students have won 45 international, national, and local awards for excellence in research, including Young Investigator Awards from the American Society for Bone and Mineral Research; a New Investigator Award from the European Calcified Tissue Society; travel awards from the International Bone and Mineral Society, American Society for Bone and Mineral Research, Japanese Society for Bone and Mineral Research, Canadian Society of Endocrinology and Metabolism, Indo-US Conference on Vitamin D, and Canadian Diabetes Association; and doctoral awards from CIHR, NSERC, and Memorial University.

CALCIUM,PHOSPHORUS AND BONE METABOLISM

The research in the lab of Dr. Kovacs is focused on the regulation of calcium and bone metabolism during the reproductive periods, including pregnancy, lactation, and fetal development. Mammalian fetuses regulate calcium and bone metabolism in a manner distinct from adults, reflecting the unique needs of the developing fetus (e.g. mineralization of skeleton, active transfer of calcium across the placenta) and the developmental roles of certain hormones (e.g. parathyroid hormone-related protein or PTHrP). Little is known about how the fetus accomplishes this regulation, or how and when the normal adult regulatory mechanisms are established after birth.  During pregnancy and especially during lactation, calcium and other minerals are borrowed from the mother's skeleton to provide to the fetus or the milk, and then the lost calcium is restored to the mother's skeleton without any permanent loss in bone strength or density. It is particularly important to determine how the mother's skeleton is able to regain bone mass so quickly and readily, because the adult skeleton is normally unable to gain bone mass that has been lost. The mother's skeleton regains bone mass after weaning at a rate that exceeds the efficacy of our current pharmacological treatments for osteoporosis.

The research largely utilizes specific transgenic and gene knockout mouse models, molecular techniques, radiological techniques (including bone mineral density by DXA on small animals), and classical physiological studies, to focus on several areas:

1)    Hormonal regulation of active placental calcium and phosphorus transfer and fetal mineral homeostasis;

2)    Molecular mechanism(s) of calcium and phosphorus transfer at the level of the trophoblasts and intraplacental yolk sac cells;

3)    Neonatal transition from fetal to adult regulatory mechanisms for mineral homeostasis;

4)    Regulation of mineral and bone homeostasis during pregnancy and lactation.

This research is being carried out with the support of collaborators at the Massachusetts General Hospital and Harvard Medical School (Boston), Harvard Dental School (Boston), Maine Medical Center Research Institute (Scarborough), Yale University (New Haven), University of Georgia (Athens), University of Melbourne (Melbourne), McGill University (Montreal), and the University of Texas M.D. Anderson Cancer Center (Houston). The research is funded by the Canadian Institutes of Health Research, the Research & Development Corporation of Newfoundland and Labrador.

Calcium Research Laboratory Staff

Christopher S. Kovacs, Principal Investigator Clinical Page - Art Site
Beth Kirby, Research Assistant
Chrissy Wells, Research Technician
Claire Lewis, Science Technician
Yue Ma, PhD student
Kamal Alhani, MSc student
Brittany Gillies, MSc student
Aaron Wiseman, MSc student
 

Public Service Announcement

The 9th International Conference on PTH and PTHrP and The Newfoundland Bone Conference
The dates are July 10-12, 2006.

Research Awards to Dr. Kovacs (not including grants):
2014 University Research Professorship, Memorial University
2003 Young Investigator Award, Canadian Society of Endocrinology and Metabolism
2003 Gold Medal Award in Medicine, Royal College of Physicians and Surgeons of Canada
2002 Antoni Nalecz Award, Canadian Society for Endocrinology and Metabolism
2002 President's Award for Outstanding Research, Memorial University
1999-04 Scholarship, CIHR (Canadian Institutes of Health Research)
1999 John C. Haddad Young Investigator Award from the American Society for Bone and Mineral Research and the Society for Advances in Mineral Metabolism
1998 D. Harold Copp Young Investigator Award - Canadian Society for Endocrinology and Metabolism
1998 Endocrine Society Travel Award
1997 NIH/Keystone Symposium on Molecular Biology Travel Award
1996 10th International Congress of Endocrinology Travel Award
1995 Young Investigator Award, American Society for Bone and Mineral Research
1994 Residents' Research Day Award, University of Alberta
1994-98 Fellowship, Medical Research Council of Canada
Distinctions
2015-19 Reappointed to Editorial Board, Journal of Bone and Mineral Research
2015-17 President, Advances in Mineral Metabolism
2014-17 Reappointed to Editorial Board, Endocrinology
2013-15 Vice-President, Advances in Mineral Metabolism
2012 Anast Lecture, Boston Children’s Hospital, Harvard Medical School, Boston
2011 Category Chair, 33rd Annual Meeting of the American Society for Bone and Mineral Research
2011 Fellow, American College of Endocrinology
2010 Ruth E. Rosevear Seminar in Maternal and Child Nutrition, University of Cincinnati
2009-12 Editorial Board, Endocrinology
2008-11 Publications Committee, American Society for Bone and Mineral Research
2008-2010 Committee on Vitamin D and Calcium, Institute of Medicine, National Academies of Science USA
2008 Program Committee and Abstract Category Chair, 30th Annual Meeting of the American Society for Bone and Mineral Research
2007 Program Committee, 29th Annual Meeting of American Society for Bone and Mineral Research
2006 Chair, Newfoundland Bone Conference
2006 Program Committee, 28th Annual Meeting of American Society for Bone and Mineral Research
2006 Needs Assessment Task Force, American Society for Bone and Mineral Research
2006-10 Gold Medal in Medicine Award Committee, Royal College of Physicians and Surgeons of Canada
2006-?? Awards Committee, Canadian Society for Clinical Investigation
2005 Program Committee, 27th Annual Meeting of American Society for Bone and Mineral Research
2004 Fast-track promotion to Full Professor
2004-09 Study Section on Skeletal Development Biology and Disease, Charter Member, National Institutes of Health
2004-14 Editorial Board, Journal of Bone and Mineral Research
2004-07 Education Committee, American Society for Bone and Mineral Research
2004-07 Editorial Board, Royal College Outlook
2004 Program Committee, 26th Annual Meeting of American Society for Bone and Mineral Research
2003-?? Hospital for Sick Children Foundation Grants Program Committee
2003-?? Councilor, Canadian Society for Clinical Investigation
2003-?? Councilor, Canadian Society of Endocrinology and Metabolism
2003 Ad Hoc Member, Endocrinology Committee, Canadian Institutes of Health Research
2003 Program Committee, 25th Annual Meeting of American Society for Bone and Mineral Research
2001-04 Advisory Committee, Ethnocultural Council of Canada
2000 Program Committee, 22nd Annual Meeting of American Society for Bone and Mineral Research
2000 Program Committee, ENDO 2000, Annual meeting of Endocrine Society
Awards to Supervised Students
2014 Dean’s Fellowship / Doctoral Award (to Brittany Gillies)
2014 Travel Award, Canadian Society of Endocrinology and Metabolism (to Yue Ma)
2014 ASBMR Young Investigator Award to attend ECTS PhD Training Course in Oxford, UK (to Yue Ma)
2014 Medical Student Achievement Award, Endocrine Society (to Sandra Cooke-Hubley)
2014 New Investigator Award, European Connective Tissue Society (to Yue Ma)
2013 Travel Award, Canadian Society of Endocrinology and Metabolism (to Manoharee Samaraweera, but unable to attend)
2013 Travel Award, International Bone and Mineral Society and Japanese Society for Bone and Mineral Research (to Sandra Cooke-Hubley)
2012 Fellow of the School of Graduate Students (to Yue Ma)
2011 Graduate Student Entrepreneur Global Champion, Entrepreneurs Organization (to Mike Wahl)
2011 National Champion, Advancing Canadian Entrepreneurship (to Mike Wahl)
2009 Dean’s Fellowship from Memorial University (to Neva J. Fudge)
2009 Travel Award, Indo-US Conference of Vitamin D, Hyderabad, India (to Neva J. Fudge)
2008 Fellow of the School of Graduate Studies (to Neva Fudge)
2008 Travel Award, Canadian Diabetes Association / Canadian Society of Endocrinology and Metabolism (to Neva J. Fudge)
2008 Mary O’Neil Award (to Neva J. Fudge)
2007 Travel Award, Canadian Diabetes Association / Canadian Society of Endocrinology and Metabolism (to Charlene S. Noseworthy)
2007 Travel Award, American Society for Bone and Mineral Research (to Charlene S. Noseworthy)
2005 Colman Graduate Student Award (to Janine P. Woodrow)
2005 Travel Award, Canadian Diabetes Association / Canadian Society of Endocrinology and Metabolism (to Kerri L. Buckle)
2005-08 CIHR Doctoral Research Award (to Janine P. Woodrow)
2005 Graduate Student Research Award, Dietitians of Canada (to Janine P. Woodrow)
2004 Harold Copp Award for Most Outstanding Abstract, Canadian Society of Endocrinology and Metabolism (to Janine P. Woodrow)
2004 Fellow of the School of Graduate Studies (to Kerri L. Buckle)
2004 Travel Award, Canadian Diabetes Association / Canadian Society of Endocrinology and Metabolism (to Janine P. Woodrow)
2004 Young Investigator Award, American Society for Bone and Mineral Research (to Charlene S. Noseworthy)
2004 Travel Award, Canadian Institutes of Health Research (to Janine P. Woodrow)
2004 Medical Student Achievement Award, Endocrine Society (to Christopher J. Sharpe)
2003 Travel Award, Canadian Diabetes Association / Canadian Society of Endocrinology and Metabolism (to Janine P. Woodrow)
2003 Fellow of the School of Graduate Studies (to Janine P.Woodrow)
2003 Fellow of the School of Graduate Studies (to Charlene S. Noseworthy)
2003 Young Investigator Award, American Society for Bone and Mineral Research (to Janine P. Woodrow)
2003 Antoni Nalecz Award for Best Abstract, Canadian Society of Endocrinology and Metabolism (to Janine P. Woodrow)
2001 Mary Pater Graduate Studies Award for Excellence in Cancer Research (to Kirsten R. McDonald)
2000 American Society for Bone and Mineral Research Travel Award (to Mandy L. Woodland)
2000 Fellow of the School of Graduate Studies (to Mandy L. Woodland)
2000 Alfred Burness Graduate Student Award (to Mandy L. Woodland)
Selected Research Articles:
Kovacs CS. Bone Development and Mineral Homeostasis in the Fetus and Neonate: Roles of the Calciotropic and Phosphotropic Hormones. Physiological Reviews, 2014; in press.
Kovacs CS. Osteoporosis presenting in pregnancy, puerperium, and lactation. Current Opinion in Endocrinology, Diabetes, and Obesity. 2014; in press.
Ma Y, Samaraweera M, Cooke-Hubley S, Kirby BJ, Karaplis AC, Lanske BL, Kovacs CS. Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization. Endocrinology 2014; 155(5):1596-1605. Epub 6 Mar 2014.
Kovacs CS. The role of PTHrP in regulating mineral homeostasis during pregnancy, lactation, and fetal/neonatal development. Clinical Reviews in Bone and Mineral Metabolism 2014; 12 (3): 142-164. Epub 14 Feb 2014.
Kovacs CS, Seshiah V, Swallow R, Jones R, Rattunde H, Woerle HJ and Broedl UC. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes, Obesity & Metabolism 2014; 16: 147-158. Epub 1 August 2013.
Kirby BJ, Ma Y, Martin HM, Buckle Favaro KL, Karaplis AC, Kovacs CS. Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone. Journal of Bone and Mineral Research 2013; 28(9): 1987-2000.
Collins JN, Kirby BJ, Woodrow JP, Rosen CJ, Gagel RF, Sims NA, Kovacs CS. Lactating Ctcgrp nulls lose twice normal bone mineral content due to fewer osteoblasts and more osteoclasts, while bone mass is fully restored post-weaning in association with upregulation of Wnt signaling and other novel genes. Endocrinology 2013; 154 (4): 1400-1413. Epub 5 Mar 2013.
Kovacs CS. Bone metabolism in the fetus and neonate. Pediatric Nephrology 2014; 29(5):793-803. Epub 26 Mar 2013.
Kovacs CS. Maternal vitamin D deficiency: fetal and neonatal implications. Seminars in Fetal & Neonatal Medicine 2013; 18(3): 129-135. Epub 13 Feb 2013. http://dx.doi.org/10.1016/j.siny.2013.01.005
Rosen CJ, Adams JS, Bikle DB, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The Nonskeletal Effects of Vitamin D: an Endocrine Society Scientific Statement. Endocrine Reviews 2012; 33(3): 456-492. Epub 17 May 2012.
Kovacs CS. The role of vitamin D in pregnancy and lactation: Insights from animal models and clinical studies. Annual Review of Nutrition. 2012; 32: 97-123. Epub 5 Apr 2012.
Kovacs CS. Calcium and bone disorders during pregnancy and lactation. Endocrinology and Metabolism Clinics of North America 2011; 40: 795–826.
Kovacs CS. Bone development in the fetus and neonate: role of the calciotropic hormones. Current Osteoporosis Reports 2011; 9: 274-83. Epub 9 Sep 2011.
Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after lactation does not require PTHrP. Journal of Bone and Mineral Research 2011; 26(6): 1242-51. Epub 1 Feb 2011
Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, Blackburn CC, Manley NR. Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Genetics 2010; 6(12):e1001251. Epub 23 Dec 2010
Simmonds CS and Kovacs CS. The role of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in regulating mineral homeostasis during fetal development. Critical Reviews in Eukaryotic Gene Expression 2010; 20(3): 235-273.
Fudge NJ, Kovacs CS. Pregnancy upregulates intestinal calcium absorption and skeletal mineralization independently of the vitamin D receptor. Endocrinology 2010; 151(3): 886-95.
Simmonds CS, Karsenty G, Karaplis AC, Kovacs CS.  Parathyroid hormone regulates fetal-placental mineral homeostasis. Journal of Bone and Mineral Research 2010; 25(3): 594-605.
Suzuki Y, Kovacs CS, Takanaga H, Peng JB, Landowski CP, Hediger MA. The calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. Journal of Bone and Mineral Research 2008; 23(8):1249-56.
Kovacs CS. Vitamin D in pregnancy and lactation: maternal, fetal and neonatal outcomes from clinical and animal studies. American Journal of Clinical Nutrition 2008;88(Suppl):520S-528S.
Woodrow JP, Sharpe CJ, Fudge NJ, Hoff AO, Gagel RF, Kovacs CS. Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation in mice. Endocrinology 2006; 147(9):4010-21.
Kovacs CS, El-Hajj Fuleihan G. Calcium and bone disorders during pregnancy and lactation. Endocrinology and Metabolism Clinics of North America 2006; 35(1): 21-51..
Kovacs CS,Woodland ML, Fudge NJ, Friel JK. The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice. American Journal of Physiology - Endocrinology and Metabolism 2005; 289(1):E133-44.
Kovacs CS. Mineral metabolism during pregnancy and lactation. Journal of Mammary Gland Biology and Neoplasia 2005; 10(2):105-118.
McDonald KR, Fudge NJ, Woodrow JP, Friel JK, Hoff AO, Gagel RF, Kovacs CS. Ablation of calcitonin/calcitonin gene related peptide-α impairs fetal magnesium but not calcium homeostasis.  American Journal of Physiology - Endocrinology and Metabolism 2004; 287(2): E218-E226.
Rubin LP, Kovacs CS, Pinar H, Tsai SW, Torday JS, Kronenberg HM. Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Developmental Dynamics 2004; 230(2): 278-289.
Fudge NJ, Kovacs CS. Physiological studies in heterozygous calcium sensing receptor ( CaSR ) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo. BMC Physiology 2004, 4:5.
Brasier G, Tikellis C, Xuereb L, Craigie J, Casley D, Kovacs CS, Fudge NJ, Kalnins R, Cooper ME, Wookey PJ. Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis. Experimental Cell Research 2004; 293:31-42.
Kovacs CS, Chafe LL, Woodland ML, McDonald KR, Fudge NJ, Wookey PJ.   Calcitropic gene expression suggests a role for intraplacental yolk sac in maternal-fetal calcium exchange. American Journal of Physiology - Endocrinology and Metabolism 2002; 282(3): E721-E732.
Kovacs, CS, Chafe LL, Fudge NJ, Friel JK, Manley NR.   PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP.  Endocrinology; 2001; 142(11): 4983-4993.
Kovacs, CS, Manley NR, Moseley JM, Martin TJ, Kronenberg HM.  Fetal parathyroids are not required to maintain placental calcium transport.  Journal of Clinical Investigation 2001;107(8):1007-1015.
Kovacs, CS.  Calcium and bone metabolism in pregnancy and lactation.  Journal of Clinical Endocrinology and Metabolism 2001;86(6): 2344-2348.
Kovacs, CS.   Exploring the normal regulation of fetal-placental calcium metabolism through the use of targeted gene ablation in fetal mice. Drug Development Research 2000; Volume 49:167-173.
Lanske B, Divieti P, Kovacs CS, Pirro A, Landis WJ, Krane SM, Bringhurst FR, Kronenberg HM. The parathyroid hormone/parathyroid hormone-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 1998;  Dec;139(12):5194-204.
Kovacs CS, Ho-Pao C, Hunzelman JL, Lanske B, Fox J, Seidman JG, Seidman CE, Kronenberg HM.   Regulation of murine fetal-placental calcium metabolism by the calcium sensing receptor. Journal of Clinical Investigation. 1998;101(12):2812-2820.
Schipani E, Lanske B, Hunzelman J, Luz A, Kovacs CS, Lee K, Pirro A, Kronenberg HM, Jppner H.   Targeted expression of constitutively active PTH/PTHrP receptors delays endochondral bone formation and rescues PTHrP-less mice. Proceedings of the National Academy of Sciences USA 1997;94(25):13689-3694.
Kovacs CS, Kronenberg HM.   Maternal-fetal calcium and bone metabolism during pregnancy, puerperium and lactation. Endocrine Reviews 1997; 18(6): 832-872.
Kovacs CS, Lanske B, Hunzelman JL, Guo J, Karaplis AC, Kronenberg HM.   Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor. Proceedings of the National Academy of Sciences USA 1996; 93(26):15233-15238.
Kovacs CS, Chik CL.  Hyperprolactinemia caused by lactation and prolactinomas is associated with altered serum calcium, phosphate, parathyroid hormone (PTH) and PTH-related peptide levels. Journal of Clinical Endocrinology and Metabolism 1995; 80(10):3036-3042.
Book Chapters:
Kovacs CS. Interactions of PTHrP with receptors and signaling. In: Bilezikian JP, Marcus R, Levine M, Marcocci C, Potts J, Silverberg S (eds). The Parathyroids, 3rd Edition. San Diego: Academic Press/Elsevier, 2014: in press.
Kovacs CS. Parathyroid function and disease during pregnancy, lactation, and fetal/neonatal development. In: Bilezikian JP, Marcus R, Levine M, Marcocci C, Potts J, Silverberg S (eds). The Parathyroids, 3rd Edition. San Diego: Academic Press/Elsevier, 2014: in press.
Kovacs CS. Hypoparathyroidism during pregnancy, lactation, and fetal/neonatal development. In: Biachi ML, Brown EM (eds). Hypoparathyroidism. Milan: Springer, 2014, in press.
Kovacs CS. Fetal calcium metabolism. In: Rosen CJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th ed. Washington, DC: ASBMR Press, 2013; pp 180-187.
Kovacs CS, Kronenberg HM. Pregnancy and lactation. In: Rosen CJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th ed. Washington, DC: ASBMR Press, 2013: pp 156-164.
Kovacs CS. Control of skeletal homeostasis during pregnancy and lactation – lessons from physiological models. Chapter 15. In: Thakker RV, Whyte MP, Eisman JA, and Igarashi T. Genetics of Bone Biology and Skeletal Disease. San Diego: Academic Press/Elsevier, 2012; p 221-240.
Kovacs CS. Fetal control of calcium and phosphate homeostasis – lessons from mouse models. Chapter 14. In: Thakker RV, Whyte MP, Eisman JA, and Igarashi T. Genetics of Bone Biology and Skeletal Disease. San Diego: Academic Press/Elsevier, 2012; p 205-220.
Kovacs CS. Calcium metabolism during pregnancy and lactation [2nd edition]. In: De Groot, LJ (Ed), www.Endotext.com, 2012.
Kovacs CS. Fetal Mineral Homeostasis. Chapter 11.  In: Glorieux FH, Pettifor JM, Jüppner H (eds): Pediatric Bone: Biology and Diseases, 2nd Edition.  San Diego: Academic Press, 2011:"p 247-275"
Kovacs CS.  Fetus and neonate. In: Feldman D, Pike WJ, Adams JS (eds), Vitamin D: Third Edition. New York: Academic Press, 2011,"p 625-646"
Kovacs CS. Calcium metabolism during pregnancy and lactation. In: De Groot, LJ (Ed), www.Endotext.com http://www.Endotext.com , 2009.
Wysolmerski JJ, Stewart AF, Kovacs CS. Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, and Pancreatic Tissues.  Chapter 29.  In:  Principles of Bone Biology, 3rd Edition, eds Bilezikian J, Raisz L, Martin TJ, Academic Press, 2008, pp. 713-731.
Kovacs CS, Kronenberg HM. Pregnancy and lactation.  In: Rosen CJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 7th ed. Washington, DC: ASBMR Press, 2008: pp. 90-95.
Kovacs CS.  Fetal calcium metabolism.  In: Rosen CJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 7th ed. Washington, DC: ASBMR Press, 2008, pp. 108-112.
Kovacs CS, Kronenberg HM. Skeletal physiology: Pregnancy and lactation. In: Favus MJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed. Washington, DC: ASBMR Press, 2006: pp. 63-68.
Kovacs CS. Skeletal physiology: Fetus and neonate. In: Favus MJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed. Washington, DC: ASBMR Press, 2006: pp. 50-55.
Kovacs CS.  Bone Physiology: Fetus and Neonate.  In: Teotia SPS (ed): An Asian Perspective on Nutritional and Metabolic Bone and Stone Disease.  New Delhi, India: CBS Publishers, 2007: 40-50.
Kovacs CS.  Bone Physiology: Pregnancy and Lactation.  In: Teotia SPS (ed): An Asian Perspective on Nutritional and Metabolic Bone and Stone Disease.  New Delhi, India: CBS Publishers, 2007: 51-62.
Kovacs CS. Fetal Mineral Homeostasis and Skeletal Mineralization.  In: Massaro EJ, Rogers J (eds): The Skeleton: Biochemical, Genetic and Molecular Interactions in Development and Homeostasis. Totowa, NJ: Humana Press, 2004: pp. 293-306.
Kovacs CS, Kronenberg HM.  Skeletal physiology: pregnancy and lactation.  In: Favus MJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. Washington, DC: ASBMR Press, 2003: pp. 80-86.
Kovacs CS, Skeletal physiology: fetus and neonate.  In: Favus MJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. Washington, DC: ASBMR Press, 2003: pp. 65-71.
Kovacs CS.  Fetal Mineral Homeostasis.  In: Glorieux FH, Pettifor JM,  Jüppner H (eds): Pediatric Bone: Biology and Diseases.  San Diego: Academic Press, 2003; pp 271-302.
Kovacs CS, Lanske B, Manley NR, Kronenberg HM.   Regulation of murine fetal--placental calcium metabolism. In Danks J, Dacke C, Flik G, Gay C (eds): Calcium Metabolism: Comparative Endocrinology. Bristol: BioScientifica, 1999: pp. 153-158.
Kovacs CS, Kronenberg HM.   Skeletal physiology during pregnancy and lactation. In: Favus MJ (ed), Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 4th ed. Philadelphia: Lippincott, Williams & Wilkins, 1999: pp. 50-54.
Kronenberg HM, Lanske B, Kovacs CS, Chung U, Lee K, Segre GV, Schipani E, Jüppner H. Functional analysis of the PTH/PTHrP network of ligands and receptors. In: Recent Progress in Hormone Research, Endocrine Society; Volume 53; 1998: 283-303.