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Michael Grant

BioMedical Sciences
PhD, McMaster 1993; MSc, UBC 1989; BSc, UBC 1978

Professor of Immunology

Division of BioMedical Sciences
Faculty of Medicine
Memorial University
300 Prince Philip Drive
St. John's, NL, Canada A1B 3V6


709 777-8292 (office), 777-8290 (lab)
709 777-8294

mgrant@mun.ca



Description of Research

My laboratory studies the immunology of chronic viral infection with a focus on human immunodeficiency virus (HIV), hepatitis C virus (HCV) and cytomegalovirus (CMV).  These viruses all have complex relationships with the immune system and a negative impact on human health.  We work with a broad collection of cell lines and viral isolates to investigate the interface between virus-infected cells and cytotoxic lymphocytes, including the CD8+ T cells and natural killer (NK) cells responsible for controlling these viruses.  The ultimate goal of this research is to develop immune-based strategies that slow the onset of immune senescence and limit the need for antiviral drugs.    

Cytomegalovirus-infected human fetal lung fibroblast cells stained with crystal violet to reveal plaques.

Hepatitis C virus-infected human hepatocellular carcinoma cells with intracellular immunofluoresecent staining for HCV core protein expression.
   
Absence of CD57+NKG2C+ NK cells in NKG2C null CMV-negative individual (a) and unusual expansion of CD57+NKG2C+ natural killer cells in HIV-infected, CMV infected individual (b).


Current research grants

2014, CIHR- Cytomegalovirus immune memory inflation and immunosenescence in HIV infection.

2012, Newfoundland and Labrador Centre for Applied Health Research- Cytomegalovirus and cognitive function in the oldest old.

2011-2014, CIHR, Heteroclitic stimulation and CD5 modulation as strategies to expand HIV-specific CD8+ T cell recognition breadth


 
Current Students, Staff and Trainees

Recent Graduates

Hassan Kofahi, PhD candidate
Adeolu Adegoke, MSc candidate
Neva Fudge, Research Assistant
Staci Stapleton, Research Assistant
Kayla Holder, Research Technician
Maureen Gallant, Research Technician
Nicholas Newbook, GTEP trainee
Joey Heath, Undergraduate trainee
Kayla Holder, MSc
Stephen Penny, MSc
Krista Gladney, MSc
Matthew Parsons, MSc
Lisa Barrett, MD/PhD


Recent Publications

Hepatitis C virus-infected cells down-regulate NKp30 and inhibit ex vivo natural killer cell functions.  K. Holder, S. Stapleton, M. Gallant, R. Russell and M. Grant.   J. Immunol., 191:3308-3318, 2013.

The anti-idiotypic antibody 1F7 stimulates monocyte interleukin-10 production and induces  endotoxin tolerance.  TK. Davtyan, DA. Poghosyan, AG. Sukiasyan and MD. Grant.  J. Inflammation, 10:14, 2013.

On the benefits of sin: Can greater understanding of the 1F7-idiotypic repertoire freeze enhance HIV vaccine development?  M. Parsons, S. Muller, H. Kohler, M. Grant and N. Bernard.  Hum Vaccin Immunother, 9:1532-1538, 2013.

Antibody responses to human immunodeficiency virus envelope from infections with multiple viral types and subtypes utilize the 1F7-idiotypic repertoire.   M. Parsons, R. Center,  J-P. Routy, D. Rouleau, R. LeBlanc, M. Wainberg, C. Tremblay, M. Zannou, S. Kent, M. Grant and N. Bernard.  AIDS Res. Human Retroviruses, 29:778-783, 2013.

Heteroclitic Peptides Enhance Human Immunodeficiency Virus-specific CD8+ T Cell Responses.  K. Gladney, J. Pohling, N. Noel, K. Zipperlen, M. Gallant and M. Grant.  Vaccine, 30:6997-7004, 2012.

Responses to pandemic AS03-adjuvanted A/California7/09 H1N1 influenza vaccine in human immunodeficiency virus-infected individuals.  D Kelly, K Burt, B Missaghi, L. Barrett, Y. Keynan, K. Fowke and M. Grant.  BMC Immunology, 13:49, 2012.

Aging, Cytomegalovirus and Human Immunodeficiency Virus Infection: A Perfect Storm.  L. Barrett, K.R. Fowke and M.D. Grant.  AIDS Reviews, 14:159-167, 2012.

Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.  M. Monajemi, C. Woodworth, J. Benkaroun, M. Grant and M. Larijani.  Retrovirology, 9:35, 2012.

Selection of human anti-HIV broadly neutralizing antibodies occurs within the context of frozen.  1F7-idiotypic repertoire.  M.S. Parsons, M. Grant, J-P. Routy, D. Rouleau, R. LeBlanc and N. Bernard.  AIDS, 25:1259-1264, 2011.

Stronger Hepatitis C Virus-specific CD8+ T Cell Responses Occur with Human Immunodeficiency Virus Coinfection.  L. Barrett, M. Gallant, C. Howley, M.I. Bowmer, G. Hirsch, K. Peltekian and M.D. Grant.  J. Viral Hepatitis, 18:170-180, 2011.