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Sheila Drover

BioMedical Sciences
M.Sc., Ph.D. Memorial

Associate Professor of Immunology

Faculty of Medicine
Memorial University of Newfoundland
Health Sciences Centre
St. John’s, NL Canada, A1B 3V6
Room: 1846/1835/1844

t: 709-864-2896 / 709-864-2897
f:
lab:

sdrover@mun.ca


THE INFLUENCE OF HLA CLASS II MOLECULES IN RHEUMATOID ARTHRITS AND BREAST CANCER

HLA genes are highly polymorphic and their products (HLA-DR, -DQ and –DP molecules) play a crucial role in regulating the immune response in health and disease. Some HLA types appear to predispose an individual to immunopathological diseases such as autoimmunity and cancer. Current research in my laboratory is aimed at elucidating the mechanism (s) for the association of HLA-DR4 with rheumatoid arthritis and how HLA-class II genes influence the outcome in breast cancer patients. Projects include:

  • Molecular analysis of HLA-DR4/peptide complexes in different types of antigen-presentation cells.
  • HLA-class II regulation and expression in synovial and breast cancer cells.
  • HLA class II genes and prognosis in breast cancer patients.
  • Th1 and Th2 profiles in carcinoma of the breast.

Research support has come from Medical Research Foundation Awards at Memorial University, Canadian Breast Cancer Foundation, Canadian Breast Cancer Research Initiative and Medical Research Council of Canada.


Selected Publications:

Drover, S. Kovats, S., Masewicz, S., Blum, J.S., and Nepom, G.T. (1998) Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM. Human Immunol. 59:77-86.

Marshall, W.H., Drover, S., Codner D., Gamberg, J., Copp, M.D., Liu, H-W., Deng, L-T., and Younghusband H.B. (1998) HLA-DP epitope typing using monoclonal antibodies. Human Immunol. 59:

Drover, S., Marshall, W.H., Kwok, W.W., Nepom, G.T. and Karr, R.W. (1994) Amino acids in the groove influence an antibody-defined disease-associated epitope. Scand. J. Immunol. 39:539-550.

Kovats, S., Drover, S., Marshall, W.H., Freed, D., Whitely, P. E., Nepom, G. T., and Blum. J. S. (1994) Coordinate defects in human histocompatibility leukocyte antigen class II expression and antigen presentation in bare lymphocyte syndrome. J. Exp. Med. 179:2017-2022.

 
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